Determination of beta-defensin genomic copy number in different populations: a comparison of three methods.
Identifieur interne : 000833 ( Main/Exploration ); précédent : 000832; suivant : 000834Determination of beta-defensin genomic copy number in different populations: a comparison of three methods.
Auteurs : Peder Fode [Danemark] ; Cathrine Jespersgaard ; Robert J. Hardwick ; Helen Bogle ; Michael Theisen ; Daniel Dodoo ; Martin Lenicek ; Libor Vitek ; Ana Vieira ; Joao Freitas ; Paal Skytt Andersen ; Edward J. HolloxSource :
- PloS one [ 1932-6203 ] ; 2011.
Descripteurs français
- KwdFr :
- Cartographie chromosomique (), Danemark, Données de séquences moléculaires, Dosage génique, Ghana, Génome humain (génétique), Génétique des populations (), Humains, Population, Portugal, Prédisposition génétique à une maladie, Royaume-Uni, République tchèque, Séquence nucléotidique, bêta-Défensines (génétique), Études de cohortes.
- MESH :
- génétique : Génome humain, bêta-Défensines.
- Cartographie chromosomique, Danemark, Données de séquences moléculaires, Dosage génique, Ghana, Génétique des populations, Humains, Population, Portugal, Prédisposition génétique à une maladie, Royaume-Uni, République tchèque, Séquence nucléotidique, Études de cohortes.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : beta-Defensins.
- genetics : Genome, Human.
- methods : Chromosome Mapping, Genetics, Population.
- Base Sequence, Cohort Studies, Czech Republic, Denmark, Gene Dosage, Genetic Predisposition to Disease, Ghana, Humans, Molecular Sequence Data, Population, Portugal, United Kingdom.
Abstract
There have been conflicting reports in the literature on association of gene copy number with disease, including CCL3L1 and HIV susceptibility, and β-defensins and Crohn's disease. Quantification of precise gene copy numbers is important in order to define any association of gene copy number with disease. At present, real-time quantitative PCR (QPCR) is the most commonly used method to determine gene copy number, however the Paralogue Ratio Test (PRT) is being used in more and more laboratories.
DOI: 10.1371/journal.pone.0016768
PubMed: 21364933
Affiliations:
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Le document en format XML
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Hardwick</name></author><author><name sortKey="Bogle, Helen" sort="Bogle, Helen" uniqKey="Bogle H" first="Helen" last="Bogle">Helen Bogle</name></author><author><name sortKey="Theisen, Michael" sort="Theisen, Michael" uniqKey="Theisen M" first="Michael" last="Theisen">Michael Theisen</name></author><author><name sortKey="Dodoo, Daniel" sort="Dodoo, Daniel" uniqKey="Dodoo D" first="Daniel" last="Dodoo">Daniel Dodoo</name></author><author><name sortKey="Lenicek, Martin" sort="Lenicek, Martin" uniqKey="Lenicek M" first="Martin" last="Lenicek">Martin Lenicek</name></author><author><name sortKey="Vitek, Libor" sort="Vitek, Libor" uniqKey="Vitek L" first="Libor" last="Vitek">Libor Vitek</name></author><author><name sortKey="Vieira, Ana" sort="Vieira, Ana" uniqKey="Vieira A" first="Ana" last="Vieira">Ana Vieira</name></author><author><name sortKey="Freitas, Joao" sort="Freitas, Joao" uniqKey="Freitas J" first="Joao" last="Freitas">Joao Freitas</name></author><author><name sortKey="Andersen, Paal Skytt" sort="Andersen, Paal Skytt" uniqKey="Andersen P" first="Paal Skytt" last="Andersen">Paal Skytt Andersen</name></author><author><name sortKey="Hollox, Edward J" sort="Hollox, Edward J" uniqKey="Hollox E" first="Edward J" last="Hollox">Edward J. Hollox</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Base Sequence</term><term>Chromosome Mapping (methods)</term><term>Cohort Studies</term><term>Czech Republic</term><term>Denmark</term><term>Gene Dosage</term><term>Genetic Predisposition to Disease</term><term>Genetics, Population (methods)</term><term>Genome, Human (genetics)</term><term>Ghana</term><term>Humans</term><term>Molecular Sequence Data</term><term>Population</term><term>Portugal</term><term>United Kingdom</term><term>beta-Defensins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cartographie chromosomique ()</term><term>Danemark</term><term>Données de séquences moléculaires</term><term>Dosage génique</term><term>Ghana</term><term>Génome humain (génétique)</term><term>Génétique des populations ()</term><term>Humains</term><term>Population</term><term>Portugal</term><term>Prédisposition génétique à une maladie</term><term>Royaume-Uni</term><term>République tchèque</term><term>Séquence nucléotidique</term><term>bêta-Défensines (génétique)</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>beta-Defensins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genome, Human</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Génome humain</term><term>bêta-Défensines</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromosome Mapping</term><term>Genetics, Population</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term><term>Cohort Studies</term><term>Czech Republic</term><term>Denmark</term><term>Gene Dosage</term><term>Genetic Predisposition to Disease</term><term>Ghana</term><term>Humans</term><term>Molecular Sequence Data</term><term>Population</term><term>Portugal</term><term>United Kingdom</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cartographie chromosomique</term><term>Danemark</term><term>Données de séquences moléculaires</term><term>Dosage génique</term><term>Ghana</term><term>Génétique des populations</term><term>Humains</term><term>Population</term><term>Portugal</term><term>Prédisposition génétique à une maladie</term><term>Royaume-Uni</term><term>République tchèque</term><term>Séquence nucléotidique</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There have been conflicting reports in the literature on association of gene copy number with disease, including CCL3L1 and HIV susceptibility, and β-defensins and Crohn's disease. Quantification of precise gene copy numbers is important in order to define any association of gene copy number with disease. At present, real-time quantitative PCR (QPCR) is the most commonly used method to determine gene copy number, however the Paralogue Ratio Test (PRT) is being used in more and more laboratories.</div></front></TEI><affiliations><list><country><li>Danemark</li></country><region><li>Hovedstaden</li></region><settlement><li>Copenhague</li></settlement></list><tree><noCountry><name sortKey="Andersen, Paal Skytt" sort="Andersen, Paal Skytt" uniqKey="Andersen P" first="Paal Skytt" last="Andersen">Paal Skytt Andersen</name><name sortKey="Bogle, Helen" sort="Bogle, Helen" uniqKey="Bogle H" first="Helen" last="Bogle">Helen Bogle</name><name sortKey="Dodoo, Daniel" sort="Dodoo, Daniel" uniqKey="Dodoo D" first="Daniel" last="Dodoo">Daniel Dodoo</name><name sortKey="Freitas, Joao" sort="Freitas, Joao" uniqKey="Freitas J" first="Joao" last="Freitas">Joao Freitas</name><name sortKey="Hardwick, Robert J" sort="Hardwick, Robert J" uniqKey="Hardwick R" first="Robert J" last="Hardwick">Robert J. Hardwick</name><name sortKey="Hollox, Edward J" sort="Hollox, Edward J" uniqKey="Hollox E" first="Edward J" last="Hollox">Edward J. Hollox</name><name sortKey="Jespersgaard, Cathrine" sort="Jespersgaard, Cathrine" uniqKey="Jespersgaard C" first="Cathrine" last="Jespersgaard">Cathrine Jespersgaard</name><name sortKey="Lenicek, Martin" sort="Lenicek, Martin" uniqKey="Lenicek M" first="Martin" last="Lenicek">Martin Lenicek</name><name sortKey="Theisen, Michael" sort="Theisen, Michael" uniqKey="Theisen M" first="Michael" last="Theisen">Michael Theisen</name><name sortKey="Vieira, Ana" sort="Vieira, Ana" uniqKey="Vieira A" first="Ana" last="Vieira">Ana Vieira</name><name sortKey="Vitek, Libor" sort="Vitek, Libor" uniqKey="Vitek L" first="Libor" last="Vitek">Libor Vitek</name></noCountry><country name="Danemark"><region name="Hovedstaden"><name sortKey="Fode, Peder" sort="Fode, Peder" uniqKey="Fode P" first="Peder" last="Fode">Peder Fode</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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